METABOLISM OF PREGNENOLONE BY HUMAN-BREAST CANCER - EVIDENCE FOR 17-ALPHA-HYDROXYLASE AND 17,20-LYASE

被引:20
作者
ABULHAJJ, YJ [1 ]
IVERSON, R [1 ]
KIANG, DT [1 ]
机构
[1] UNIV MINNESOTA,DEPT MED,MINNEAPOLIS,MN 55455
关键词
D O I
10.1016/0039-128X(79)90094-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The metabolism of 7- 3H-pregnenolone was studied in vitro using 16 human breast carcinomas. All mammary tumors transformed pregnenolone to progesterone. All estrogen receptor poor tumors and 4 out of 8 estrogen receptor rich tumors converted pregnenolone to 17-hydroxypregnenolone. Five estrogen receptor poor tumors showed the presence of 17,20-lyase as evidenced by formation of dehydroepiandro-sterone and androstenedione. In two estrogen receptor poor tumors, conversions of pregnenolone to progesterone, 17-hydroxy pregnenolone, dehydroepiandrosterone androstenedione and finally to estradiol was documented, providing a hypothetical pathway for steroid metabolism in human breast cancer. The conversion of pregnenolone to 17-hydroxy-pregnenolone was significantly less in receptor rich tumors and was totally absent in 4 receptor rich tumors with estrogen receptors of over 45 fmol/mg protein. © 1979.
引用
收藏
页码:817 / 827
页数:11
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