WOUND-HEALING OF BURNS IN RATS TREATED WITH A NEW AMINO-ACID COPOLYMER MEMBRANE

被引：10

作者：

ELOY, R ^{[1
]}

CORNILLAC, AM ^{[1
]}

机构：

[1] BIOMATECH SA,CHASSE SUR RHONE,FRANCE

来源：

BURNS | 1992年 / 18卷 / 05期

关键词：

D O I：

10.1016/0305-4179(92)90041-R

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

A new amino acid copolymer (leucine + methylglutamate) membrane which is moderately permeable to water vapour, impermeable to bacteria, non-biodegradeable and stable, has been developed as a bum wound covering. In an experimental model in the rat, excised bum lesions were covered either with the membrane or with conventional petrolatum-impregnated gauze. Morphometric analyses and histological investigations performed on days 7, 14, 21 and 42, suggested a significantly increased rate of healing for wounds covered with the polymeric membrane as compared with those covered with impregnated gauze. No wound dessication, fluid retention or exudate was observed under the membrane due to its moderate permeability to water vapour. The wounds covered with impregnated gauze also showed a marked inflammatory response in the granulation tissue, which remained even at day 42. This appearance was very different from a normal dermis or a polymeric membrane treated dermis.

引用

页码：405 / 411

页数：7

共 18 条

[1]

Aiba, Minoura, Fujiwara, Et al., Laminates composed of polypeptides and elastomers as a bum wound covering physicochemical properties, Biomaterials, 6, (1985)

[2]

Anderson, Gibbons, Martin, Et al., The potential of poly amino acids as biomaterials, J. Biomed. Mater. Res., 5, (1974)

[3]

Baux, Mimoun, Faivre, Et al., Experimental Study and Clinical Application of a New Temporary Skin Substitute: INERPAN, Communication at the 8th International Congress of Bum Injuries, (1990)

[4]

Bruin, Jonkman, Meijer, Et al., A new porous polyurethane wound covering, J. Biomed. Mater. Res., 24, (1990)

[5]

Chan, Vincent, Wangelann, Accelerated healing of carbon dioxide laser burns in rats treated with composite polyurethane dressings, Arch. Dermatol., 123, (1987)

[6]

Costagliola, INERPAN, A multi-center Controlled Study in the Treatment of Second Degree Bums in Adults and Children, Communication at the 8th International Congress of Burn Injuries, (1990)

[7]

Dagnelie, Théorie et méthodes statistiques, Presse agronomique Gembloux, pp. 1-2, (1975)

[8]

Eloy, Weill, Preclinical studies of PA 186, a temporary skin substitute, 3rd Congress of the European Bums Association, (1989)

[9]

Eloy, Brack, Dorme, Et al., Physical and chemical properties of a new synthetic aminoacid copolymer used as wound dressing, a new temporary skin substitute — physical and biological properties, J. Biomed. Mater. Res., 26, (1992)

[10]

Faivre, Mimoun, De Saint Maur, Et al., Substitut cutané — Etude experimentale chez le rat, IX Congrés de la Société Française d'Etude et de Traitment des Brûlures, (1988)

← 1 2 →