THERMOREGULATORY RESPONSES FOLLOWING INJECTION OF 5-HYDROXYTRYPTAMINE INTO THE SEPTOHIPPOCAMPAL COMPLEX IN RATS

被引：12

作者：

CUI, Y ^{[1
]}

LEE, TF ^{[1
]}

WANG, LCH ^{[1
]}

机构：

[1] UNIV ALBERTA, DEPT ZOOL, BIOL SCI BLDG, EDMONTON T6G 2E9, ALBERTA, CANADA

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1993年 / 45卷 / 04期

关键词：

5-HYDROXYTRYPTAMINE; THERMOREGULATION; LATERAL SEPTUM; HIPPOCAMPUS; HYPOTHERMIA; HEAT PRODUCTION;

D O I：

10.1016/0091-3057(93)90143-H

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The present study investigated the change in thermoregulatory responses following microinjection of 5-hydroxytryptamine (5-HT) into the lateral septum and the hippocampus of unanesthetized, unrestrained rats. Intraseptal injection of 5-HT (5 to 20 mug) caused a dose-related fall in core temperature (T(b)), which was associated with a decrease in heat production (HP). As the decrease in HP can not completely account for the magnitude of the decrease in T(b), increase in heat loss may also be involved in the 5-HT-induced hypothermia. In contrast to observed changes following intraseptal injection, no significant change in either T(b) or HP was observed after microinjection of the same doses of 5-HT into the hippocampal areas, indicating that the hypothermic response to intraseptal injection of 5-HT is site specific. Further, the hypothermic response to intraseptal injection of 5-HT was only attenuated by systemic pretreatment with cyproheptadine, but not by naloxone or scopolamine, indicating that the hypothermic response is mediated by 5-HT receptor, but not by endogenous opioid and cholinergic systems.

引用

页码：935 / 939

页数：5

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