INDUCTION OF MICRONUCLEI IN PERIPHERAL-BLOOD AND BONE-MARROW ERYTHROCYTES OF RATS AND MICE EXPOSED TO 1,3-BUTADIENE BY INHALATION

被引：46

作者：

AUTIO, K

RENZI, L

CATALAN, J

ALBRECHT, OE

SORSA, M

机构：

[1] INST OCCUPAT HLTH,MOLEC & CELLULAR TOXICOL LAB,SF-00250 HELSINKI,FINLAND

[2] UNIV PADUA,DEPT BIOL,I-35121 PADUA,ITALY

[3] UNIV ZARAGOZA,DEPT GENET,E-50013 ZARAGOZA,SPAIN

[4] UNIV WURZBURG,INST TOXICOL,W-8700 WURZBURG,GERMANY

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1994年 / 309卷 / 02期

基金：

芬兰科学院;

关键词：

1,3-BUTADIENE; MICRONUCLEUS; ACRIDINE ORANGE; INHALATION EXPOSURE;

D O I：

10.1016/0027-5107(94)90108-2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Female CB6F1 mice and male Wistar rats were exposed to different concentrations of 1,3-butadiene (1,3-BD) by inhalation. Micronucleus tests using both peripheral brood erythrocytes and femoral marrow cells of these animals were performed. Cells were stained either using conventional acridine orange (AO) staining or supravitally using AO-coated slides. Dose-dependent increases in the frequency of micronuclei (MN) were observed both in blood and in bone marrow cells in mice. 1,3-BD did not, however, increase the frequency of MN in either blood or bone marrow cells of rats at any of the tested concentrations.

引用

页码：315 / 320

页数：6

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