Hexasomy of chromosome 8 and trisomy of chromosome 11 characterize two karyotypically independent clones in a case of acute non-lymphocytic leukemia - Conventional cytogenetic and FISH investigation

被引：9

作者：

Trakhtenbrot, L ^{[1
]}

Rosner, E ^{[1
]}

Gipsh, N ^{[1
]}

Berman, S ^{[1
]}

Sofer, G ^{[1
]}

BrokSimoni, F ^{[1
]}

Rechavi, G ^{[1
]}

BenBassat, I ^{[1
]}

机构：

[1] TEL AVIV UNIV,SACKLER FAC MED,IL-69978 TEL AVIV,ISRAEL

来源：

CANCER GENETICS AND CYTOGENETICS | 1995年 / 85卷 / 01期

关键词：

D O I：

10.1016/0165-4608(95)00107-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A case of ANLL following a myelodysplastic syndrome, probably resulting from occupational exposure to ionizing irradiation, with two cytogenetically unrelated clones, hexasomy 8 and trisomy 11, was investigated by conventional cytogenetics and FISH. Significant quantitative differences between data obtained by metaphase and interphase analysis of the hexasomy 8 clone were observed. A difference in the sensitivity to chemotherapy of the two clones was found: while the hexasomy 8 clone markedly decreased in response to treatment, the trisomy 11 clone remained unchanged.

引用

页码：1 / 4

页数：4

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