ANTIBODY-RESPONSES OF HUMAN-LYMPHOCYTES INVITRO - SPECIFICITY AND PHYSICAL-PROPERTIES OF PLAQUE-FORMING CELL PRECURSORS

被引：7

作者：

FINLAY, GJ ^{[1
]}

BOOTH, RJ ^{[1
]}

MARBROOK, J ^{[1
]}

机构：

[1] UNIV AUCKLAND,DEPT MED,AUCKLAND,NEW ZEALAND

来源：

AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE | 1979年 / 57卷 / DEC期

关键词：

D O I：

10.1038/icb.1979.62

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

When human tonsillar lymphocytes are cultured with pokeweed mitogen they generate a large number of antibody-secreting cells. A substantial number of the plaque-forming cells generated have specificity for sheep erythrocytes but very few are specific for either bovine or horse erythrocytes. We have investigated the physical properties of sheep erythrocyte-specific precursors and have found that they have the characteristics of larger lymphocytes and are heterogeneous with respect to density. Our results support the concept that the percursors which can be induced by pokeweed mitogen to develop into plaque-forming cells belong to a pre-activated sub-population of lymphocytes.

引用

页码：587 / 596

页数：10

共 21 条

[1]

BAUMOHL Z, 1977, CLIN EXP IMMUNOL, V28, P116

[2] MICROCULTURE SYSTEM FOR GENERATING HEMOLYTIC ANTIBODY-RESPONSES FROM HUMAN TONSILLAR LYMPHOCYTES [J].