ACUTE TOLERANCE TO THE EXCITATORY EFFECT OF ENKEPHALIN MICRO-INJECTIONS INTO HIPPOCAMPUS

被引：65

作者：

ELAZAR, Z ^{[1
]}

MOTLES, E ^{[1
]}

ELY, Y ^{[1
]}

SIMANTOV, R ^{[1
]}

机构：

[1] WEIZMANN INST SCI,DEPT GENET,REHOVOT,ISRAEL

来源：

LIFE SCIENCES | 1979年 / 24卷 / 06期

关键词：

D O I：

10.1016/0024-3205(79)90176-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Microinjections of 1-20 μg of leu-enkephalin were done in the dorsal hippocampus of cats and rats in acute experiments. Long lasting epileptiform changes in the hippocampal EEG were produced. These changes were prevented by previous microinjections of naloxone at the same site. When repeated microinjections of the same dose of enkephalin which initially was epileptogenic were done a progressive loss of effectiveness of the drug was observed. Also, progressively higher doses of enkephalin were necessary to produce effects comparable to the effect of the initial injection. These results suggest that acute tolerance may develop to the epileptogenic effect of leu-enkephalin in hippocampus. © 1979.

引用

页码：541 / 548

页数：8

共 19 条

[1] ANALGESIA INDUCED INVIVO BY CENTRAL ADMINISTRATION OF ENKEPHALIN IN RAT [J].