RAPID, SENSITIVE GLC DETERMINATION OF PENTOBARBITAL AND OTHER BARBITURATES IN SERUM USING NITROGEN-SPECIFIC DETECTOR

被引：14

作者：

SUN, SR

HOFFMAN, DJ

机构：

[1] Pharmaceutical Product Division, Abbott Laboratories, North Chicago, Illinois

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 03期

关键词：

Barbiturates; various—GLC analysis in serum; GLC—analysis; pentobarbital and various barbiturates in serum; Pentobarbital—GLC analysis in serum; Sedatives—pentobarbital and various barbiturates; GLC analysis in serum;

D O I：

10.1002/jps.2600680339

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A GLC method for the analysis of pentobarbital in serum was developed. After extraction from serum, a methyl derivative was prepared and quantitated by nitrogen‐specific detection. The method has a sensitivity of 0.08 μg/ml for pentobarbital with only 0.1 ml of serum. Secobarbital was the internal standard. Derivatives of other barbiturates also were prepared. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：386 / 388

页数：3

共 14 条

[1] GAS-CHROMATOGRAPHIC ANALYSIS OF COMMONLY PRESCRIBED BARBITURATES AT THERAPEUTIC AND OVERDOSE LEVELS IN PLASMA AND URINE [J].