INDUCTION OF NORMAL ULTRASTRUCTURE BY CGRP TREATMENT IN DYSGENIC MYOTUBES

被引：21

作者：

GARCIA, L

PINCONRAYMOND, M

ROMEY, G

CHANGEUX, JP

LAZDUNSKI, M

RIEGER, F

机构：

[1] CNRS,UPR 411,INST PHARMACOL MOLEC & CELLULAIRE,660 ROUTE LUCIOLES,F-06560 VALBONNE,FRANCE

[2] INSERM,U153,BIOL & PATHOL NEUROMUSCULAIRES GRP,F-06560 VALBONNE,FRANCE

[3] INST PASTEUR,UNITE NEUROBIOL MOLEC,F-75724 PARIS 15,FRANCE

[4] INST PASTEUR,DEPT BIOTECHNOL,CNRS,UNITE 041149,F-75724 PARIS 15,FRANCE

来源：

FEBS LETTERS | 1990年 / 263卷 / 01期

关键词：

Ca[!sup]2+[!/sup] channel; Calcitonin gene-related peptide; Excitation-contraction coupling; Muscle; Muscular dysgenesis; Triad;

D O I：

10.1016/0014-5793(90)80725-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The calcitonin gene-related peptide (CGRP) restores an apparant normal ultrastructure in mdg/mdg muscle cells in vitro, including a normal triadic organization which is known to be essential for excitation-contraction (E-C) coupling. However, neither slow L-type Ca2+ channel activity nor E-C coupling, which are absent in mdg/mdg muscle, were re-established. These observations suggest a potential role of CGRP (and also ofcAMP as the intracellular messenger) in the morphological development of the muscle fiber. © 1990.

引用

页码：147 / 152

页数：6

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