PROSTACYCLIN (PGI2) EFFECTS ON ANTERIOR-PITUITARY HORMONES IN THE RAT INVIVO

被引：14

作者：

KIMBALL, FA ^{[1
]}

PORTEUS, SE ^{[1
]}

KIRTON, KT ^{[1
]}

FRIELINK, RD ^{[1
]}

CREASY, DM ^{[1
]}

DAYAN, AD ^{[1
]}

机构：

[1] WELLCOME RES LABS,DEPT PATHOL,RES TRIANGLE PK,NC 27709

来源：

PROSTAGLANDINS | 1979年 / 18卷 / 03期

关键词：

D O I：

10.1016/S0090-6980(79)80056-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intravenous injection of 600 μg PGE2 or PGI2 significantly increased serum LH and prolactin levels in estradiol treated ovariectomized rats. There was no effect on serum FSH concentration. PGE2 and PGI2 stimulated LH release in a non-dose dependent manner, while prolactin levels were positively correlated with the dose administered following PGI2 treatment. 6-keto-PGF1α at a comparable dose had no effect on pituitary hormone levels. Subcutaneous administration of 1 mg/kg or 60 mg/kg PGI2 for seven days significantly depressed serum LH level both in male and female rats. These doses had no effect on serum FSH or prolactin levels. © 1979.

引用

页码：377 / 385

页数：9

共 17 条

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