CATABOLISM OF CALCITONIN GENE-RELATED PEPTIDE AND SUBSTANCE-P BY NEUTRAL ENDOPEPTIDASE

被引：95

作者：

KATAYAMA, M

NADEL, JA

BUNNETT, NW

DIMARIA, GU

HAXHIU, M

BORSON, DB

机构：

[1] UNIV CALIF SAN FRANCISCO,CARDIOVASC RES INST,BOX 0911,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,DEPT PHYSIOL,SAN FRANCISCO,CA 94143

[3] UNIV CALIF SAN FRANCISCO,DEPT SURG,SAN FRANCISCO,CA 94143

[4] UNIV CALIF SAN FRANCISCO,DEPT MED,SAN FRANCISCO,CA 94143

来源：

PEPTIDES | 1991年 / 12卷 / 03期

关键词：

ENKEPHALINASE; CALLA; CD10; NEUTRAL METALLOENDOPEPTIDASE; EC-342411; PEPTIDASE INHIBITORS; PEPTIDASES; ENZYME KINETICS; HPLC;

D O I：

10.1016/0196-9781(91)90102-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Calcitonin gene-related peptide (CGRP) and substance P (SP) are released from sensory nerves upon exposure to irritating stimuli. Neutral endopeptidase (NEP), a membrane-bound peptidase, cleaves many peptides including SP, thereby limiting their biological actions. Recombinant NEP cleaved CGRP1 approximately 88-fold less rapidly than it cleaved SP. The slow cleavage by NEP of CGRP compared to SP suggests that this enzyme is likely to have weaker physiologic effects on CGRP than have been demonstrated for SP.

引用

页码：563 / 567

页数：5

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