REDUCTION OF TRANSMURAL ESOPHAGEAL VARICEAL PRESSURE BY METOCLOPRAMIDE

被引：25

作者：

KLEBER, G ^{[1
]}

SAUERBRUCH, T ^{[1
]}

FISCHER, G ^{[1
]}

GEIGENBERGER, G ^{[1
]}

PAUMGARTNER, G ^{[1
]}

机构：

[1] MUNICIPAL HOSP MUNICH SCHWABING,MUNICH,GERMANY

来源：

JOURNAL OF HEPATOLOGY | 1991年 / 12卷 / 03期

关键词：

D O I：

10.1016/0168-8278(91)90840-8

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In nineteen patients with portal hypertension and oesophageal varices, transmural variceal blood pressure was determined endoscopically by direct puncture of the varices before and after intravenous administration of 20 mg metoclopramide or placebo. No change in pressure was observed after placebo (mean difference -1.3 +/- 24.5%, N.S.), however, metoclopramide reduced the pressure by 17.6 +/- 18.6% (p = 0.02). Our results suggest that metoclopramide may be beneficial for the prevention or treatment of variceal haemorrhage.

引用

收藏

页码：362 / 366

页数：5

相关论文

共 13 条

[1] MEASUREMENT OF AZYGOUS VENOUS-BLOOD FLOW BY A CONTINUOUS THERMAL DILUTION TECHNIQUE - AN INDEX OF BLOOD-FLOW THROUGH GASTROESOPHAGEAL COLLATERALS IN CIRRHOSIS [J].

BOSCH, J ;

GROSZMANN, RJ .

HEPATOLOGY, 1984, 4 (03) :424-429

[2] DOMPERIDONE-INDUCED INCREASE IN LOWER ESOPHAGEAL SPHINCTER PRESSURE DOES NOT AFFECT AZYGOUS BLOOD-FLOW IN PATIENTS WITH CIRRHOSIS [J].

BRAILLON, A ;

CAPRONCHIVRAC, D ;

VALLA, D ;

LEE, SS ;

CAPRON, JP ;

LEBREC, D .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1986, 21 (09) :1080-1082

[3]

COHEN S, 1976, GASTROENTEROLOGY, V70, P484

[4]

FEU F, 1988, Journal of Hepatology, V7, pS31

[5] 3-DIMENSIONAL VIEW OF THE VASCULAR STRUCTURE OF THE LOWER ESOPHAGUS IN CLINICAL PORTAL-HYPERTENSION [J].

HASHIZUME, M ;

KITANO, S ;

SUGIMACHI, K ;

SUEISHI, K .

HEPATOLOGY, 1988, 8 (06) :1482-1487

[6] PHARMACOLOGICAL CONSTRICTION OF THE LOWER ESOPHAGEAL SPHINCTER - A SIMPLE METHOD OF ARRESTING VARICEAL HEMORRHAGE [J].

HOSKING, SW ;

DOSS, W ;

ELZEINY, H ;

ROBINSON, P ;

BARSOUM, MS ;

JOHNSON, AG .

GUT, 1988, 29 (08) :1098-1102

[7] SOMATOSTATIN DOES NOT REDUCE ESOPHAGEAL VARICEAL PRESSURE IN LIVER CIRRHOTICS [J].

KLEBER, G ;

SAUERBRUCH, T ;

FISCHER, G ;

PAUMGARTNER, G .

GUT, 1988, 29 (02) :153-156

[8] PRESSURE OF INTRAESOPHAGEAL VARICES ASSESSED BY FINE NEEDLE PUNCTURE - ITS RELATION TO ENDOSCOPIC SIGNS AND SEVERITY OF LIVER-DISEASE IN PATIENTS WITH CIRRHOSIS [J].

KLEBER, G ;

SAUERBRUCH, T ;

FISCHER, G ;

PAUMGARTNER, G .

GUT, 1989, 30 (02) :228-232

[9] PHARMACOLOGIC INFLUENCE ON ESOPHAGEAL-VARICES - A PRELIMINARY-REPORT [J].

LUNDERQUIST, A ;

ALWMARK, A ;

GULLSTRAND, P ;

HALLANGERAS, M ;

JOELSSON, B ;

OWMAN, T ;

PETTERSSON, KI ;

TRANBERG, KG .

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 1983, 6 (02) :65-71

[10] EFFECTS OF METOCLOPRAMIDE AND DOMPERIDONE ON AZYGOUS VENOUS-BLOOD FLOW IN PATIENTS WITH CIRRHOSIS AND PORTAL-HYPERTENSION [J].

MASTAI, R ;

GRANDE, L ;

BOSCH, J ;

BRUIX, J ;

RIGAU, J ;

KRAVETZ, D ;

NAVASA, M ;

PERA, C ;

RODES, J .

HEPATOLOGY, 1986, 6 (06) :1244-1247