CAMP ACTIVATES CL-/HCO3- EXCHANGE FOR REGULATION OF INTRACELLULAR PH IN RENAL EPITHELIAL-CELLS

被引：11

作者：

HARADA, H

KANAI, Y

ANZAI, M

SUKETA, Y

机构：

[1] Department of Environmental Biochemistry and Toxicology, University of Shizuoka, School of Pharmaceutical Sciences, Shizuoka, Yada

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1092卷 / 03期

关键词：

PH; INTRACELLULAR; CAMP; CL(-)-HCC3- EXCHANGE; (LLC-PK1 CELL);

D O I：

10.1016/S0167-4889(97)90020-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The role of cAMP in regulation of intracellular pH in the confluent LLC-PK1 cells was investigated. DibutyrylcAMP and forskolin induce intracellular acidification. This acidification is inhibited by DIDS and ethacrynic acid, inhibitors of Na+-independent Cl-/HCO3- exchange, and by removal of extracellular Cl-. In addition, Bt2 cAMP causes Cl- entry into LLC-PK, cells. These results suggest that cAMP activates Cl- transport, namely Na+-independent Cl-/HCO3- exchange, which participates in pH(i) regulation.

引用

页码：404 / 407

页数：4

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