PRODUCTION OF THROMBIN AND ANTITHROMBIN-III BY BRAIN AND ASTROGLIAL CELL-CULTURES

被引:89
作者
DESCHEPPER, CF
BIGORNIA, V
BERENS, ME
LAPOINTE, MC
机构
[1] UNIV CALIF SAN FRANCISCO,BRAIN TUMOR RES CTR,SAN FRANCISCO,CA 94143
[2] UNIV CALIF SAN FRANCISCO,METAB RES UNIT,SAN FRANCISCO,CA 94143
来源
MOLECULAR BRAIN RESEARCH | 1991年 / 11卷 / 3-4期
关键词
ANTITHROMBIN-III; THROMBIN; SERPIN; ASTROCYTE;
D O I
10.1016/0169-328X(91)90045-Y
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
There is increasing evidence that some proteases and protease inhibitors are produced within the central nervous system. It has been proposed that the balance between these two classes of proteins may be an important modulator of brain cell growth and differentiation. Here we report that antithrombin III (ATIII) is produced in brain and primary astroglial cultures. In addition, we show that human astroglial cultures contain prothrombin mRNA, and secrete a thrombin-like protein that makes complexes with antithrombin III.
引用
收藏
页码:355 / 358
页数:4
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