ANTIFUNGAL COMBINATION THERAPY IN LOCALIZED CANDIDOSIS

被引：6

作者：

POLAK, A

机构：

[1] Fa. Hoffmann - La Roche Ltd., CH-4002 Basel

来源：

MYCOSES | 1990年 / 33卷 / 7-8期

关键词：

CANDIDOSIS; MOUSE MODEL; COMBINATION THERAPY; ANTIFUNGAL DRUGS; AMPHOTERICIN-B; FLUCYTOSINE; IMIDAZOLES; TRIAZOLES; FLUCONAZOLE; ICI-195,739; ITRACONAZOLE; KETOCONAZOLE; RESISTANCE;

D O I：

10.1111/myc.1990.33.7-8.353

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

A mouse model of localized candidosis in air-filled subcutaneous cysts imitating thrush has been developed. We have now tested various antifungal combinations in this animal model. Flucytosine (5-FC) + amphotericin B (Amph B) showed the highest efficacy, a clear additive or even synergistic effect was seen. The combination of 5-FC + imidazole or triazole derivative was less efficacious, an additive effect was rare. The combination of 5-FC + Amph B was also tested against Candida albicans strains showing various degrees of 5-FC-resistance. A significant reduction in 5-FC-resistant mutants was seen after the treatment with the combination.

引用

页码：353 / 358

页数：6

共 7 条

[1] ORAL CANDIDIASIS IN HIGH-RISK PATIENTS AS THE INITIAL MANIFESTATION OF THE ACQUIRED IMMUNODEFICIENCY SYNDROME [J].