HEPATIC TOXICITY OF ADJUVANT CHEMOTHERAPY FOR CARCINOMA OF THE BREAST

被引：20

作者：

VAUGHAN, WP

WILCOX, PM

ALDERSON, PO

ETTINGER, DS

ABELOFF, MD

机构：

[1] Johns Hopkins Oncology Center, Johns Hopkins University School of Medicine, Baltimore

[2] Department of Radiology, Division of Nuclear Medicine, Johns Hopkins University School of Medicine, Baltimore

来源：

MEDICAL AND PEDIATRIC ONCOLOGY | 1979年 / 7卷 / 04期

关键词：

adjuvant chemotherapy; breast cancer; CMF; hepatic toxicity; methotrexate;

D O I：

10.1002/mpo.2950070410

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Four patients developed abnormal liver function tests and focal defects on liver scan while receiving cyclosphosphamide, methotrexate and 5‐fluorouracil as adjuvant chemotherapy following mastectomy for breast cancer. Liver biopsies showed severe focal inflammation. The biopsy findings and the subsequent clinical course of the patients strongly suggest that these abnormalities were due to hepatic toxicity of the chemotherapy and not metastic breast cancer. A review of serial liver function tests performed on 24 patients in that chemotherapy program revealed that four out of eight patients with elevated alkaline phosphatase prior to therapy developed early metastatic cancer. Elevated alkaline phosphatase occurring during chemotherapy on the other hand was quite common but more likely due to hepatic toxicity of the drugs. The development of abnormal liver function tests even in association with focal defects on liver scan is not sufficient to diagnose metastatic breast cancer in patients receiving adjuvant chemotherapy. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：351 / 359

页数：9

共 16 条

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