TRANSGENIC MICE EXPRESSING HUMAN CD14 ARE HYPERSENSITIVE TO LIPOPOLYSACCHARIDE

被引：191

作者：

FERRERO, E ^{[1
]}

JIAO, D ^{[1
]}

TSUBERI, BZ ^{[1
]}

TESIO, L ^{[1
]}

RONG, GW ^{[1
]}

HAZIOT, A ^{[1
]}

GOYERT, SM ^{[1
]}

机构：

[1] CORNELL UNIV,N SHORE UNIV HOSP,COLL MED,DEPT MED,DIV MOLEC MED,350 COMMUNITY DR,MANHASSET,NY 11030

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 06期

关键词：

MONOCYTES; ENDOTOXIN SHOCK;

D O I：

10.1073/pnas.90.6.2380

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

In vitro studies have previously shown that the myelomonocytic differentiation antigen CD14 is a receptor for a complex consisting of lipopolysaccharide (LPS) and LPS-binding protein. To investigate the role of CD14 in vivo and its relationship to induction of LPS-induced endotoxin shock, transgenic mice expressing human CD14 were produced. These mice express human CD14 strongly on the surface of their monocytes, neutrophils, and Thy-1(+) lymphocytes and are hypersensitive to LPS, as evidenced by their increased susceptibility to endotoxin shock. These results document the importance of CD14 in vivo as a primary mediator of this lethal syndrome. Furthermore, these mice provide an important model for testing the therapeutic effects of agents directed specifically against the human, as opposed to the murine, CD14 protein in preventing LPS-induced endotoxin shock.

引用

页码：2380 / 2384

页数：5

共 36 条

[1]

[Anonymous], 1986, MANIPULATING MOUSE E

[2]

MONOCLONAL-ANTIBODIES TO NOVEL MYELOID ANTIGENS REVEAL HUMAN NEUTROPHIL HETEROGENEITY [J].