MACROLIDE ANTIBIOTICS PROTECT NEURONS IN CULTURE AGAINST THE N-METHYL-D-ASPARTATE (NMDA) RECEPTOR-MEDIATED TOXICITY OF GLUTAMATE

被引：27

作者：

MANEV, H ^{[1
]}

FAVARON, M ^{[1
]}

CANDEO, P ^{[1
]}

FADDA, E ^{[1
]}

LIPARTITI, M ^{[1
]}

MILANI, D ^{[1
]}

机构：

[1] FIDIA RES LABS,I-35031 ABANO TERME,ITALY

来源：

BRAIN RESEARCH | 1993年 / 624卷 / 1-2期

关键词：

MACROLIDE ANTIBIOTIC; FK-506; EXCITOTOXICITY; N-METHYL-D-ASPARTATE; GLUTAMATE; CEREBELLAR GRANULE NEURON; CALCIUM; 3-(2-CARBOXYPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID;

D O I：

10.1016/0006-8993(93)90098-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The immunosuppressive macrolide FK-506 has been shown to protect neurons in culture against glutamate excitotoxicity. This effect was attributed to the binding of immunosuppressants to calcineurin-inhibiting immunophilins. We now report that also the non-immunosuppressive macrolide antibiotics protect neurons in culture against NMDA- but not kainate-mediated excitotoxicity. The effect was structure-dependent: larger macrolide rings were more active. Macrolides did not affect the 3-(2-carboxypiperazin-4yl)-propyl-1-phosphonic acid (CPP) binding or the NMDA-mediated calcium influx.

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收藏

页码：331 / 335

页数：5

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