Transgenic approaches to understanding the mechanisms of chemical carcinogenesis in mouse skin

被引：16

作者：

Brown, K

Burns, PA

Balmain, A

机构：

[1] CRC Beatson Laboratories, Department of Medical Oncology, University of Glasgow, Bearsden, Glasgow

来源：

TOXICOLOGY LETTERS | 1995年 / 82-3卷

关键词：

papilloma; squamous carcinoma; H-ras oncogene; p53 Tumour suppressor gene; malignant conversion; tumour stem cell;

D O I：

10.1016/0378-4274(95)03549-4

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The use of animal models for human cancer has proved effective in the elucidation of those molecular events which are responsible for the various stages of tumour development. Chemical carcinogenesis in mouse skin has been studied as a model for human squamous cancer for several decades, and analysis of this model has led to the identification of a number of the changes which are involved in the evolution of malignancy. The use of transgenic and knockout mice offers a further avenue of advancement, allowing refinement of the model, and the ability to examine the consequences of individual events in vivo in greater detail. Additionally, crossing different transgenic or knockout animals represents a powerful tool to study the cumulative effects of several genetic alterations acting in concert.

引用

页码：123 / 130

页数：8

共 20 条

[1] SKIN HYPERKERATOSIS AND PAPILLOMA FORMATION IN TRANSGENIC MICE EXPRESSING A RAS ONCOGENE FROM A SUPRABASAL KERATIN PROMOTER [J].