ROLE OF ADENOSINE IN THE TREATMENT OF MYOCARDIAL STUNNING

被引：18

作者：

FORMAN, MB

VELASCO, CE

机构：

[1] Department of Medicine, Division of Cardiology, Vanderbilt University School of Medicine, Nashville, TN

[2] Division of Cardiology, Vanderbilt University Medical Center, Nashville, 37232-2170, TN

来源：

CARDIOVASCULAR DRUGS AND THERAPY | 1991年 / 5卷 / 05期

关键词：

ADENOSINE; ADENOSINE TRIPHOSPHATE; REGIONAL BLOOD FLOW; FREE RADICALS; CALCIUM HOMEOSTASIS; STUNNING;

D O I：

10.1007/BF00053551

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adenosine is an endogenous nucleoside produced from the breakdown of adenosine triphosphate (ATP) that possesses a number of complex cellular and metabolic effects that could ameliorate postischemic contractile dysfunction (myocardial stunning). Potential mechanisms include the repletion of high-energy phosphate stores, reduced myocardial oxygen consumption, a decrease in oxygen-derived free radicals, restoration of calcium homeostasis, and an increase in regional myocardial blood flow. Experimental studies have shown that adenosine can reduce myocardial stunning with or without a concomitant increase in the total myocardial ATP stores. Adenosine may be a useful pharmacologic strategy in the prevention and treatment of ventricular dysfunction following episodes of regional or global ischemia, although further studies are needed to clarify the precise cellular mechanisms involved.

引用

页码：901 / 908

页数：8

共 65 条

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