CARDIOACTIVE PROPERTIES OF SC4453, A DIGOXIN ANALOG WITH A BETA-PYRIDAZINE-C-17 RING

被引：18

作者：

GODFRAIND, T ^{[1
]}

GHYSELBURTON, J ^{[1
]}

机构：

[1] CATHOLIC UNIV LOUVAIN, PHARMACODYNAMIE GEN & PHARMACOL LAB, B-1200 BRUSSELS, BELGIUM

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 60卷 / 04期

关键词：

C[!sub]17β[!/sub]-Pyridazine; Digoxin; Myocardial contractility; Na pump;

D O I：

10.1016/0014-2999(79)90238-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

SC4453 is a digoxin analog with a pyridazine instead of a lactone ring in C17.beta.. SC4453 was compared with digoxin with respect to effect on contractility and on activity of the Na pump in guinea pig isolated left atria stimulated at 3.3 Hz. The 2 glycosides stimulated the Na pump at low concentrations and inhibited the Na pump at high concentrations. At the time to peak inotropic effect, for a similar inhibition of the Na pump, the increase in systolic tension was higher with SC4453 than with digoxin, but the increase in diastolic tension was similar for both. The inhibition of the Na pump is apparently not the only mechanism responsible for the positive inotropic effect of cardiac glycosides.

引用

页码：337 / 344

页数：8

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