LASER-INDUCED THROMBOSIS TEST SUITABLE FOR PHARMACOLOGICAL SCREENING STUDIES

被引：26

作者：

KOVACS, IB

GOROG, P

机构：

[1] EGYT PHARMACOCHEM WORKS,DEPT PHARMACOL,H-1475 BUDAPEST,HUNGARY

[2] KORVIN OTTO HOSP,H-1071 BUDAPEST,HUNGARY

来源：

MICROVASCULAR RESEARCH | 1979年 / 18卷 / 03期

关键词：

D O I：

10.1016/0026-2862(79)90046-3

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The fine details of the in vivo technique for producing thrombus formation in microcirculation by HeNe laser are described. The criteria of assessing the thrombotic reaction in the mesenteric arteries and veins of mice and venules of the mesoappendix of rats are established. Validity of the test is demonstrated by two potent antiplatelet drugs, aspirin and Fludilat. The method, performed especially in mice, is highly suitable for screening compounds for antithrombotic effects. © 1979.

引用

页码：403 / 412

页数：10

共 14 条

[1]

AMBRUS JL, 1976, J MED, V7, P439

[2]

DUVAL DL, 1970, MAYO CLIN PROC, V45, P388

[3] EFFECT OF EVANS BLUE ON BLOOD-PLATELETS AND MICROVASCULAR HEMOSTASIS [J].