ABNORMAL LIPOPROTEIN-LIPASE-MEDIATED PLASMA TRIGLYCERIDE REMOVAL IN UNTREATED DIABETES-MELLITUS ASSOCIATED WITH HYPERTRIGLYCERIDEMIA

被引:87
作者
BRUNZELL, JD [1 ]
PORTE, D [1 ]
BIERMAN, EL [1 ]
机构
[1] VET ADM HOSP,SEATTLE,WA 98108
来源
METABOLISM-CLINICAL AND EXPERIMENTAL | 1979年 / 28卷 / 09期
基金
美国国家卫生研究院;
关键词
D O I
10.1016/0026-0495(79)90089-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Hypertriglyceridemia is common in untreated diabetes mellitus. An abnormality in the interaction of lipoprotein lipase with endogenous circulating plasma lipoprotein triglyceride has been demonstrated in untreated diabetes. These diabetics have a decreased maximal removal capacity for plasma triglyceride (27.0 mg TG/kg/hr) and increased Km (390 mg/dl) for endogenous plasma triglyceride-lipoprotein lipase interaction compared to that found in nondiabetic hypertriglyceridemic subjects (Vmax, 32.0; km, 157). Diabetics treated for at least two months have a maximal removal capacity and Km similar to that of nondiabetic subjects (Vmax, 32.7; Km, 192). No evidence for an increase in triglyceride production due to diabetes per se was found. When diabetic subjects with triglyceride levels over 400 mg/dl were selected for study, most were found to have an independent familial form of hypertriglyceridemia. © 1979.
引用
收藏
页码:901 / 907
页数:7
相关论文
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