STIMULANT EFFECT OF THE BETA-CARBOLINE FG-7142 IN THE OPEN-FIELD TEST

被引：11

作者：

BRUHWYLER, J ^{[1
]}

CHLEIDE, E ^{[1
]}

HOUBEAU, G ^{[1
]}

MERCIER, M ^{[1
]}

机构：

[1] UNIV NAMUR,FAC MED,DEPT EXPTL PSYCHOL,B-5000 NAMUR,BELGIUM

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 200卷 / 01期

关键词：

FG-7142; BENZODIAZEPINE INVERSE AGONISTS; ANXIOGENIC ACTIVITY; OPEN FIELD; ANXIETY; (RAT);

D O I：

10.1016/0014-2999(91)90685-J

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The anxiogenic activity of N-methyl-beta-carboline-3-carboxamide (FG 7142) is sometimes difficult to observe in rats. As the open field has recently been applied successfully to test the anxiogenic potential of n-butyl-beta-carboline-3-carboxylate (beta-CCB) in mice, a comparable experiment was performed with FG 7142 (1, 5, 10, 30 mg/kg i.p.) in rats. In contrast to the inhibitory effects measured with beta-CCB, FG 7142 significantly increased the ambulation and rearing scores and induced aggressivity in some animals. A differential sensitivity of mice and rats to beta-carbolines, predominant analeptic properties of FG 7142, and differences in the types of anxiety induced are proposed to account for this discrepancy.

引用

页码：183 / 185

页数：3

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