MURINE SURVIVAL OF LETHAL IRRADIATION WITH THE USE OF HUMAN UMBILICAL-CORD BLOOD

被引：10

作者：

ENDE, N

PONZIO, NM

ATHWAL, RS

ENDE, M

GIULIANI, DC

机构：

[1] SOUTHSIDE REG MED CTR,DEPT LAB MED & PATHOL,PETERSBURG,VA

[2] SOUTHSIDE REG MED CTR,DIV MED HEMATOL,PETERSBURG,VA

[3] SOUTHSIDE REG MED CTR,DEPT MICROBIOL & MOLEC GENET,PETERSBURG,VA

来源：

LIFE SCIENCES | 1992年 / 51卷 / 16期

关键词：

D O I：

10.1016/0024-3205(92)90013-F

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We have found that human umbilical cord blood (HUCB) will routinely protect mice exposed to lethal levels of irradiation. At the end of 50 days, over seventy percent (70%) of mice injected with HUCB survived 900 cGy or irradiation, which produced 100% deaths in the uninjected control animals. Moreover, there was some evidence that human colony stimulating factors further improved survival. Anti-Natural Killer cell (NK) antibody was utilized along with HUCB in these studies, however, Anti-NK cell serum alone had no radioprotective effect in mice. The studies reported here suggest the possibility of utilizing HUCB for immediate protection of humans from lethal irradiation.

引用

页码：1249 / 1253

页数：5

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