A DOSE-FINDING STUDY OF MILTEFOSINE (HEXADECYLPHOSPHOCHOLINE) IN PATIENTS WITH METASTATIC SOLID TUMORS

被引:65
作者
VERWEIJ, J
PLANTING, A
VANDERBURG, M
STOTER, G
机构
[1] Department of Medical Oncology, Rotterdam Cancer Institute/Daniel den Hoed Kliniek, Rotterdam, 3075 EA
关键词
MILTEFOSINE; HEXADECYLPHOSPHOCHOLINE; DOSE FINDING; SOLID TUMORS;
D O I
10.1007/BF01211805
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The ether lipid miltefosine (hexadecylphosphocholine) was orally given to patients with various tumours in a dose-finding study. All patients initially received a daily total dose of 100 mg, which in the absence of side-effects was increased to 150 mg and further to 200 mg. A total of 54 patients were entered and were evaluable for gastrointestinal toxicity. Nausea and vomiting were found to be dose-limiting; 22% of patients ultimately tolerated a dose of 100 mg, 59% tolerated a dose of 150 mg and 19% tolerated a dose of 200 mg. In addition 30% of patients developed renal dysfunction, which was thought to be related to the drug. No other toxities were observed. For further phase II studies it is recommended that one starts with a dose of 150 mg daily, divided over three administrations.
引用
收藏
页码:606 / 608
页数:3
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