ENVIRONMENTAL-TEMPERATURE VARIATIONS CAUSE DEGRADATIONS IN EPINEPHRINE CONCENTRATION AND BIOLOGICAL-ACTIVITY

被引：34

作者：

GRANT, TA ^{[1
]}

CARROLL, RG ^{[1
]}

CHURCH, WH ^{[1
]}

HENRY, A ^{[1
]}

PRASAD, NH ^{[1
]}

ABDELRAHMAN, AA ^{[1
]}

ALLISON, EJ ^{[1
]}

机构：

[1] E CAROLINA UNIV,DEPT EMERGENCY MED,GREENVILLE,NC 27834

来源：

AMERICAN JOURNAL OF EMERGENCY MEDICINE | 1994年 / 12卷 / 03期

关键词：

BREAKDOWN; CATECHOLAMINE; EMERGENCY MEDICAL SERVICES; HEAT;

D O I：

10.1016/0735-6757(94)90148-1

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

This study determined the biological consequence of temperature induced epinephrine degradation. Two different epinephrine preparations (1:1,000 and 1:10,000) were exposed to either cold (5°C) or hot (70°C) temperatures. The exposure occurred for 8-hour periods each day in 4-, 8-, and 12-week intervals. Samples and identical controls were then chemically evaluated using high-pressure liquid chromatography (HPLC), and biological activity of samples showing chemical degradation was assessed in conscious rats. Epinephrine (1:10,000) underwent a significant degradation and a loss of concentration of the parent compound after 8 weeks of heat treatment. By 12 weeks, 64% of the epinephrine was degraded. A smaller (30%) but significant loss of cardiovascular potency was determined by blood pressure and heart rate responses in conscious rats. The degradation of epinephrine (1:1,000) was not statistically significant even after 12 weeks of heat exposure. No change was noted from control in either epinephrine concentration when exposed to cold temperatures. In conclusion, epinephrine (1:10,000) deteriorates in the presence of elevated temperature and should be protected from high temperatures when carried by EMS providers. The degradation products may possess biological activity. © 1994.

引用

页码：319 / 322

页数：4

共 13 条

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