PERIPHERAL ADMINISTRATION OF PICROTOXIN AND BICUCULLINE STIMULATES INVIVO SOMATOSTATIN RELEASE FROM RAT MEDIAN-EMINENCE

被引：16

作者：

ARANCIBIA, S

BRIOZZO, P

机构：

[1] Laboratory of Endocrinological Neurobiology, URA 1197 of CNRS, University of Montpellier II, Montpellier

来源：

NEUROSCIENCE LETTERS | 1990年 / 111卷 / 1-2期

关键词：

Push-pull perfusion; Somatostatin release; γ-Aminobutyric acid-A receptor;

D O I：

10.1016/0304-3940(90)90370-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The γ-Aminobutyric acid-A (GABAA) antagonist picrotoxin and bicuculline were administered to male rats to determine their effects on somatostatin (SRIF) release, measured in unanesthetized animals stereotaxically implanted with push-pull cannula in the median eminence (ME). I.p. injection (3 mg/kg) of picrotoxin (n=5) or bicuculline (n=6) significantly increased (35.4±10.8 vs 13.7±4.3 pg/15 min; P<0.03 and 38±3.5 vs 14±1.8 pg/15 min; P<0.001, respectively) SRIF release from the ME compared to baseline levels measured in the same animals. In contrast, with local perfusion of picrotoxin, (10-4 to 10-6 M) SRIF release from the ME was not affected. These data suggest a physiological endogenous inhibitory tone of GABA on SRIF release. © 1990.

引用

页码：211 / 216

页数：6

共 24 条

[1]

ARANCIBIA S, 1987, ANN ENDOCRINOL-PARIS, V48, P410

[2] INVIVO RELEASE OF SOMATOSTATIN FROM RAT MEDIAN-EMINENCE AFTER LOCAL K+ INFUSION OR DELIVERY OF NOCICEPTIVE STRESS [J].