BULLATALICINONE, A NEW POTENT BIOACTIVE ACETOGENIN, AND SQUAMOCIN FROM ANNONA-BULLATA (ANNONACEAE)

被引：21

作者：

HUI, YH ^{[1
]}

RUPPRECHT, JK ^{[1
]}

ANDERSON, JE ^{[1
]}

WOOD, KV ^{[1
]}

MCLAUGHLIN, JL ^{[1
]}

机构：

[1] PURDUE UNIV,SCH PHARM & PHARMACEUT SCI,DEPT MED CHEM & PHARMACOGNOSY,W LAFAYETTE,IN 47907

来源：

PHYTOTHERAPY RESEARCH | 1991年 / 5卷 / 03期

关键词：

ANNONA-BULLATA RICH (ANNONACEAE); BULLATALICINONE; SQUAMOCIN; BRINE SHRIMP LETHALITY; SELECTIVE CYTOTOXICITIES; HUMAN TUMOR CELLS;

D O I：

10.1002/ptr.2650050308

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Further fractionation of the EtOH extract of the bark of Annona bullata Rich. (Annonaceae) has led to the isolation of a new nonadjacent bis-tetrahydrofuran acetogenin, bullatalicinone, and the known adjacent bis-tetrahydrofuran acetogenin, squamocin. These two compounds showed potent and selective cytotoxicities for certain human tumor cell lines. Their structures have been elucidated by chemical and spectral methods. Bullatalicinone is the methylketo-lactone derivative of bullatalicin which we found previously in this plant.

引用

页码：124 / 129

页数：6

共 20 条

[1] THE RELATIVE CONFIGURATION OF ACETOGENINS ISOLATED FROM ANNONA-SQUAMOSA - ANNONIN-I (SQUAMOCIN) AND ANNONIN-VI [J].

BORN, L ;

LIEB, F ;

LORENTZEN, JP ;

MOESCHLER, H ;

NONFON, M ;

SOLLNER, R ;

WENDISCH, D .

PLANTA MEDICA, 1990, 56 (03) :312-316

[2] CELL-SURFACE ANTIGENS OF HUMAN MALIGNANT-MELANOMA - MIXED HEMADSORPTION ASSAYS FOR HUMORAL IMMUNITY TO CULTURED AUTOLOGOUS MELANOMA CELLS [J].

CAREY, TE ;

TAKAHASHI, T ;

RESNICK, LA ;

OETTGEN, HF ;

OLD, LJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (09) :3278-3282

[3]

CASSADY JM, 1988, NATURAL PRODUCTS CHE, V3, P291

[4] ROLLINICIN AND ISOROLLINICIN, CYTO-TOXIC ACETOGENINS FROM ROLLINIA-PAPILIONELLA [J].

DABRAH, TT ;

SNEDEN, AT .

PHYTOCHEMISTRY, 1984, 23 (09) :2013-2016

[5] MODIFICATION AND EVALUATION OF THE POTATO DISK ASSAY AND ANTI-TUMOR SCREENING OF EUPHORBIACEAE SEEDS [J].

FERRIGNI, NR ;

PUTNAM, JE ;

ANDERSON, B ;

JACOBSEN, LB ;

NICHOLS, DE ;

MOORE, DS ;

MCLAUGHLIN, JL ;

POWELL, RG ;

SMITH, CR .

JOURNAL OF NATURAL PRODUCTS, 1982, 45 (06) :679-686

[6]

Fogh J, 1975, HUMAN TUMOR CELLS IN, P115, DOI DOI 10.1007/978-1-4757-1647-4_5

[7] CHEMISTRY OF BRAZILIAN LAURACEASE .42. RUBRENOLIDE AND RUBRYNOLIDE - ALKENE-ALKYNE PAIR FROM NECTANDRA-RUBRA [J].

FRANCA, NC ;

GOTTLIEB, OR ;

COXON, DT .

PHYTOCHEMISTRY, 1977, 16 (02) :257-262

[8]

FUJIMOTO Y, 1988, CHEM PHARM BULL, V36, P4802

[9] IN-VITRO CULTIVATION OF HUMAN TUMORS - ESTABLISHMENT OF CELL LINES DERIVED FROM A SERIES OF SOLID TUMORS [J].

GIARD, DJ ;

AARONSON, SA ;

TODARO, GJ ;

ARNSTEIN, P ;

KERSEY, JH ;

DOSIK, H ;

PARKS, WP .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1973, 51 (05) :1417-1423

[10] ON THE STEREOCHEMISTRY OF THE BISTETRAHYDROFURANYL MOIETY OF UVARICIN - PROTON CHEMICAL-SHIFTS CAN PLAY A CRUCIAL ROLE IN COMPLEX STRUCTURE DETERMINATION [J].

HOYE, TR ;

SUHADOLNIK, JC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (14) :4402-4403

← 1 2 →