学术探索
学术期刊
新闻热点
数据分析
智能评审

TRANSIENT RELEASE OF LIPID PEROXIDES AFTER CORONARY-ARTERY BALLOON ANGIOPLASTY

被引：100
作者：
ROBERTS, MJD
YOUNG, IS
TROUTON, TG
TRIMBLE, ER
KHAN, MM
WEBB, SW
WILSON, CM
PATTERSON, GC
ADGEY, AAJ
机构：
[1] ROYAL VICTORIA HOSP,REG MED CARDIOL CTR,BELFAST BT12 6BA,NORTH IRELAND
[2] QUEENS UNIV BELFAST,DEPT CHEM PATHOL,BELFAST BT7 1NN,ANTRIM,NORTH IRELAND
来源：
LANCET | 1990年 / 336卷 / 8708期
关键词：
D O I：
10.1016/0140-6736(90)91661-S
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Free radical production may cause myocardial damage during reperfusion of ischaemic myocardial tissue; when free radicals interact with polyunsaturated fatty acids or their esters, lipid peroxides are produced. A product of lipid peroxidation, malondialdehyde, was measured in 10 subjects with stable angina who underwent angioplasty of a proximal high-grade stenosis (over 90%) of the left anterior descending coronary artery. In all subjects the duration of balloon occlusion was 60 s. Blood was withdrawn from the great cardiac vein immediately before balloon inflation (T0), immediately after balloon deflation (T60), 15 s after balloon deflation (T75), and 1 min after balloon deflation (T120). There was a significant increase in malondialdehyde at T60 compared with T0 for the first balloon inflation (mean increase 0·3 μmol/l [95% confidence limits 0·1, 0·5]), and at both T60 (0·31 μmol/l [0·15, 0·47]) and T75 (0·22 μmol/l [0·04. 0·40]) for the second balloon inflation. This model could be used to assess antioxidant effects of drugs. © 1990.
引用
收藏
页码：143 / 145
页数：3
相关论文
共 19 条
12