EFFECT OF DIETARY OILS ON THE PRODUCTION OF N-3 AND N-6 METABOLITES OF LEUKOCYTE 5-LIPOXYGENASE IN 5 RAT STRAINS

被引：40

作者：

CLELAND, LG

JAMES, MJ

GIBSON, RA

HAWKES, JS

BETTS, WH

机构：

[1] FLINDERS UNIV, MED CTR, DEPT PAEDIAT, BEDFORD PK, SA 5042, AUSTRALIA

[2] QUEEN ELIZABETH HOSP, RHEUMATOL UNIT, WOODVILLE, SA 5011, AUSTRALIA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1043卷 / 03期

基金：

英国医学研究理事会;

关键词：

(Rat); 5-Lipoxygenase; Fatty acid; Icosapentaenoic acid; Leukotriene; Oil;

D O I：

10.1016/0005-2760(90)90024-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We examined the influence of various dietary oils, including linseed and fish oil on the relative rates of leukotriene B4 (LTB4) and LTB5 production by rat peritoneal exudate cells in five rat strains. While there was an association between the membrane phospholipid levels of the fatty acid precursors (arachidonic acid (AA) and eicosapentaenoic acid (EPA)) and the rate of synthesis of their respective 5-lipoxygenase products (LTB4 and LTB5), the rate of LTB4 synthesis was a combined function of both AA and EPA levels. We observed a strong linear relationship (correlation coefficient = 0.99) between the ratio of EPA/AA in the cell membrane phospholipids and the ratio of LTB5/LTB4 produced by these cells in vitro; this association was independent of genetic (strain) variability and was independent of the source of EPA (dietary EPA or EPA endogenously synthesized from dietary α-linolenic acid). © 1990.

引用

页码：253 / 258

页数：6

共 17 条

[1]

CLELAND LG, 1988, J RHEUMATOL, V15, P1471

[2] INHIBITION OF PROSTAGLANDIN BIOSYNTHESIS BY EICOSAPENTAENOIC ACID [J].