MURINE CANDIDIASIS - SEX-DIFFERENCES IN THE SEVERITY OF TISSUE LESIONS ARE NOT ASSOCIATED WITH LEVELS OF SERUM-C3 AND SERUM-C5

被引：16

作者：

ASHMAN, RB

KAY, PH

LYNCH, DM

PAPADIMITRIOU, JM

机构：

来源：

IMMUNOLOGY AND CELL BIOLOGY | 1991年 / 69卷

关键词：

D O I：

10.1038/icb.1991.2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mice deficient in the fifth component of complement are known to be extremely susceptible to lethal challenge with Candida albicans. However, male mice, that have significantly higher concentrations of serum C5 than females, were markedly more susceptible to infection. This difference was observed in both susceptible (CBA/H) and resistant (BALB/c) mice. Levels of serum C3 likewise showed no correlation with susceptibility.

引用

收藏

页码：7 / 10

页数：4

相关论文

共 22 条

[1]

Ashman R B, 1989, Immunol Ser, V47, P347

[2] MURINE CANDIDIASIS - PATHOGENESIS AND HOST RESPONSES IN GENETICALLY DISTINCT INBRED MICE [J].

ASHMAN, RB ;

PAPADIMITRIOU, JM .

IMMUNOLOGY AND CELL BIOLOGY, 1987, 65 :163-171

[3] WHATS NEW IN THE MECHANISMS OF HOST-RESISTANCE TO CANDIDA-ALBICANS INFECTION [J].

ASHMAN, RB ;

PAPADIMITRIOU, JM .

PATHOLOGY RESEARCH AND PRACTICE, 1990, 186 (04) :527-534

[4] SEXUAL DIMORPHISM OF THE 5TH COMPONENT OF MOUSE COMPLEMENT [J].

BABA, A ;

FUJITA, T ;

TAMURA, N .

JOURNAL OF EXPERIMENTAL MEDICINE, 1984, 160 (02) :411-419

[5] MOUSE COMPLEMENT - EFFECT OF SEX HORMONES AND CASTRATION ON 2 OF LATE-ACTING COMPONENTS [J].

CHURCHILL, WH ;

WEINTRAUB, RM ;

BORSOS, T ;

RAPP, HJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1967, 125 (04) :657-+

[6] DISTRIBUTION INHERITANCE + PROPERTIES OF ANTIGEN MUBI + ITS RELATION TO HEMOLYTIC COMPLEMENT [J].

CINADER, B ;

WARDLAW, AC ;

DUBISKI, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 1964, 120 (05) :897-&

[7] INTRAGASTRIC COLONIZATION OF INFANT MICE WITH CANDIDA-ALBICANS INDUCES SYSTEMIC IMMUNITY DEMONSTRABLE UPON CHALLENGE AS ADULTS [J].

DOMER, JE .

JOURNAL OF INFECTIOUS DISEASES, 1988, 157 (05) :950-958

[8] ROLE OF COMPLEMENT IN HOST DEFENSE AGAINST EXPERIMENTAL DISSEMINATED CANDIDIASIS [J].

GELFAND, JA ;

HURLEY, DL ;

FAUCI, AS ;

FRANK, MM .

JOURNAL OF INFECTIOUS DISEASES, 1978, 138 (01) :9-16

[9] AN IC3B RECEPTOR ON CANDIDA-ALBICANS - STRUCTURE, FUNCTION, AND CORRELATES FOR PATHOGENICITY [J].

GILMORE, BJ ;

RETSINAS, EM ;

LORENZ, JS ;

HOSTETTER, MK .

JOURNAL OF INFECTIOUS DISEASES, 1988, 157 (01) :38-46

[10] USE OF DBA/2N MICE IN MODELS OF SYSTEMIC CANDIDIASIS AND PULMONARY AND SYSTEMIC ASPERGILLOSIS [J].

HECTOR, RF ;

YEE, E ;

COLLINS, MS .

INFECTION AND IMMUNITY, 1990, 58 (05) :1476-1478