MORPHINE SUPPRESSION OF SUBSTANTIA NIGRA ZONA RETICULATA NEURONS IN THE RAT - IMPLICATED ROLE FOR A NOVEL STRIATONIGRAL FEEDBACK MECHANISM

被引：35

作者：

FINNERTY, EP ^{[1
]}

CHAN, SHH ^{[1
]}

机构：

[1] INDIANA STATE UNIV,DEPT LIFE SCI,TERRE HAUTE,IN 47809

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 59卷 / 3-4期

关键词：

Caudate nucleus; Dopamine; Morphine; Naloxone; Rat; Substantia nigra;

D O I：

10.1016/0014-2999(79)90296-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In lightly anesthetized rats, systemic administration of morphine exerted a naloxone-reversible suppression of spontaneously discharging neurons located primarily in the substantia nigra zona reticula, either at rest or after their activation by microinjection into the caudate nucleus. Inactivation of these neurons within the striatonigral feedback pathway is suggested to complement a direct action on the nigrostriatal dopaminergic cells by the opiate, resulting the morphine suppression of caudate neuronal activities. © 1979.

引用

页码：307 / 310

页数：4

共 9 条

[1] D-AMPHETAMINE-INDUCED INHIBITION OF CENTRAL DOPAMINERGIC-NEURONS - MEDIATION BY A STRIATO-NIGRAL FEEDBACK PATHWAY
BUNNEY, BS
AGHAJANIAN, GK
[J]. SCIENCE, 1976, 192 (4237) : 391 - 393
[2] CARLSSON A, 1963, ACTA PHARMACOL TOX, V20, P140
[3] INHIBITION OF DOPAMINE RELEASE IN CAT CAUDATE-NUCLEUS BY NIGRAL APPLICATION OF GLYCINE
CHERAMY, A
NIEOULLON, A
GLOWINSKI, J
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1978, 47 (02) : 141 - 147
[4] REGULATION OF NIGRO-STRIATAL DOPAMINERGIC NEUROTRANSMISSION IN RAT
DRAY, A
FOWLER, LJ
OAKLEY, NR
SIMMONDS, MA
TANNER, T
[J]. NEUROPHARMACOLOGY, 1977, 16 (7-8) : 511 - 518
[5] IWATSUBO K, 1977, J PHARMACOL EXP THER, V202, P429
[6] INVOLVEMENT OF DOPAMINERGIC NEUROTRANSMISSION IN INHIBITORY EFFECT OF MORPHINE ON CAUDATE NEURON ACTIVITIES
LEE, CM
WONG, PCL
CHAN, SHH
[J]. NEUROPHARMACOLOGY, 1977, 16 (09) : 571 - 576
[7] RESPONSE OF DOPAMINE NEURONS IN SUBSTANTIA NIGRA TO MUSCIMOL
MACNEIL, D
GOWER, M
SZYMANSKA, I
[J]. BRAIN RESEARCH, 1978, 154 (02) : 401 - 403
[8] LOCALIZATION OF OPIATE RECEPTORS AND ENKEPHALINS IN RAT STRIATUM IN RELATIONSHIP WITH NIGROSTRIATAL DOPAMINERGIC SYSTEM - LESION STUDIES
POLLARD, H
LLORENS, C
SCHWARTZ, JC
GROS, C
DRAY, F
[J]. BRAIN RESEARCH, 1978, 151 (02) : 392 - 398
[9] EFFECT OF MUSCIMOL ON SINGLE UNIT-ACTIVITY OF SUBSTANTIA-NIGRA DOPAMINE NEURONS
WALTERS, JR
LAKOSKI, JM
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1978, 47 (04) : 469 - 471

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