AUGMENTATION OF PROSTAGLANDIN-E2 PRODUCTION BY MAMMALIAN PHOSPHOLIPASE-A2 ADDED EXOGENOUSLY

被引：73

作者：

HARA, S ^{[1
]}

KUDO, I ^{[1
]}

INOUE, K ^{[1
]}

机构：

[1] UNIV TOKYO, FAC PHARMACEUT SCI, BUNKYO KU, TOKYO 113, JAPAN

来源：

JOURNAL OF BIOCHEMISTRY | 1991年 / 110卷 / 02期

关键词：

D O I：

10.1093/oxfordjournals.jbchem.a123550

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rat group II phospholipase A2 added exogenously to A23187-activated HL-60 granulocytes augmented their production of prostaglandin E2. Human group II phospholipase A2 and porcine group I phospholipase A2 augmented the prostaglandin E2 production in a similar manner. No significant increase in prostaglandin E2 production was observed when cells were treated with purified phospholipase A2 in the absence of A23187. Extracellular phospholipase A2 at inflamed sites may contribute to the generation of pro-inflammatory lipid mediators by hydrolyzing the cellular phospholipids of activated inflammatory cells.

引用

页码：163 / 165

页数：3

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