EFFECTS OF ULTRAVIOLET-IRRADIATION ON NATURAL-KILLER-CELL FUNCTION IN SYSTEMIC LUPUS-ERYTHEMATOSUS

被引：6

作者：

NIVED, O

JOHANSSON, I

STURFELT, G

机构：

[1] Department of Rheumatology, University Hospital, S 221 85, Lund

来源：

ANNALS OF THE RHEUMATIC DISEASES | 1992年 / 51卷 / 06期

关键词：

D O I：

10.1136/ard.51.6.726

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In vitro irradiation with long wavelength ultraviolet light (UV-A), in clinically relevant dosages, of a natural killer cell line containing cell preparations from 17 control subjects reduced natural killer cell cytotoxicity with the cell line K562 as target. The spontaneous function of natural killer cells from 12 patients with systemic lupus erythematosus (SLE) correlated inversely with the one hour erythrocyte sedimentation rate, but not with glucocorticoid doses. After UV-A exposure, natural killer cells from patients with SLE exert either increased or decreased cytotoxicity, and the direction of change is inversely correlated with the spontaneous natural killer cell function.

引用

页码：726 / 730

页数：5

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