THE ROLE OF DEHYDROALANINE IN CATALYSIS BY HISTIDINE AMMONIA-LYASE

被引：51

作者：

LANGER, M ^{[1
]}

PAULING, A ^{[1
]}

RETEY, J ^{[1
]}

机构：

[1] UNIV KARLSRUHE,INST ORGAN CHEM,D-76128 KARLSRUHE,GERMANY

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 13-14期

关键词：

DEHYDROALANINE; ENZYME CATALYSIS; HISTIDINE; REACTION MECHANISMS;

D O I：

10.1002/anie.199514641

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Not the α‐amino group but the 5‐position of the imidazole ring functions as a nucleophile towards the prosthetic dehydroalanine residue in the deamination of histidine catalyzed by histidine ammonia lyase (HAL) [Eq. (a)]. The results discussed here strongly support this proposal. (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：1464 / 1465

页数：2

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