DYNAMIC BEHAVIOR OF CHEMOSTAT SUBJECT TO SUBSTRATE INHIBITION

A theoretical study was made on the dynamic behavior of a single‐vessel continuous fermentation subject to a growth inhibition at, high concentration of the rate limiting substrate. Phase plane plotting and stability analysis showed three steady states to exist; namely, a “washout”; state, a nontrivial stable state, and an unstable state. Whether the system attains a nontrivial steady state or is to be washed‐out depends upon the initial values of the cell and/or substrate concentration(s). Since this property is a characteristic feature of the present system, an experimental procedure was suggested to insure a stable operation in practice. Copyright © 1969 John Wiley & Sons, Inc.