ACTIVATION OF REDUCING AGENTS - SODIUM HYDRIDE CONTAINING COMPLEX REDUCING AGENTS .36. STEREOSELECTIVE REDUCTION OF ALKYLCYCLOHEXANONES AND RIGID KETONES BY MCRAS

被引：15

作者：

FORT, Y ^{[1
]}

FEGHOULI, A ^{[1
]}

VANDERESSE, R ^{[1
]}

CAUBERE, P ^{[1
]}

机构：

[1] FAC SCI VANDOEUVRE NANCY,CHIM ORGAN LAB 1,CNRS,UNITE RECH 457,DOMAINE SCI VICTOR GRIGNARD,F-54506 VANDOEUVRE NANCY,FRANCE

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 23期

关键词：

D O I：

10.1021/jo00310a026

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The stereoselectivity of reduction of selected ketones by a variety of Complex Reducing Agents (resulting from the Aggregative Activation of NaH and symbolized MCRA's) has been investigated. The stereochemistry of reduction is shown to be dependent on the nature of the metal. Steric hindrance plays an important role and the apparent size of the reagents follows the trend MnCRA's > ZnCRA's, CdCRA's > NiCRA's, CoCRA's. On the other hand NiCRA's and CoCRA's have been found as very strong isomerizing reagents. Insertion of the metal species into the C-0 bond with formation of metallacycles appears as one of the possible mechanisms intervening during the reduction of ketones by MCRA's. © 1990, American Chemical Society. All rights reserved.

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页码：5911 / 5915

页数：5

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