A CASE OF LINEAR IGA BULLOUS DERMATOSIS OF CHILDHOOD - IMMUNOELECTRON MICROSCOPIC AND IGA SUBCLASS STUDIES

被引：13

作者：

ONODERA, Y

HASHIMOTO, T

MIYAKAWA, S

SHIMIZU, H

NISHIKAWA, T

YAMAMOTO, K

机构：

[1] KEIO UNIV,SCH MED,DEPT DERMATOL,35 SHINANOMACHI,SHINJU KU,TOKYO 160,JAPAN

[2] NATL CHILDRENS HOSP,DERMATOL SECT,TOKYO 154,JAPAN

来源：

DERMATOLOGICA | 1990年 / 180卷 / 04期

关键词：

Bullous disease; IgA subclass; Immunoelectron microscopy; Linear IgA bullous dermatosis;

D O I：

10.1159/000248045

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

A 2-year-old girl developed small tense bullae on the diaper area, face and extremities. Immunofluores- cent studies revealed linear deposits of IgA, IgM and C3 at the basement membrane zone (BMZ). In addition, IgA2 deposits, as well as IgAl, were clearly demonstrated in the lesional skin. However, in circulation, only IgAl anti-BMZ antibodies were found. Immunoelectron microscopic study showed IgA deposits just underneath the basilar surface of the basal cells, which seemed to be associated with hemidesmosomes. The survey of the literature suggests that the involvement of IgA2 is extremely rare in this disease. © 1990 S. Karger AG, Basel.

引用

页码：267 / 271

页数：5

共 27 条

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[2]

CHORZELSKI TP, 1979, IMMUNOPATHOLOGY SKIN, P316

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