2 INTRAGENIC POLYMORPHISMS OF THE APC-GENE DETECTED BY PCR AND ENZYMATIC DIGESTION

被引：42

作者：

KRAUS, C ^{[1
]}

BALLHAUSEN, WG ^{[1
]}

机构：

[1] UNIV ERLANGEN NURNBERG,INST HUMAN GENET,SCHWABACHANLAGE 10,W-8520 ERLANGEN,GERMANY

来源：

HUMAN GENETICS | 1992年 / 88卷 / 06期

关键词：

D O I：

10.1007/BF02265305

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The gene causing adenomatous polyposis coli (APC) has recently been cloned. Three intragenic polymorphism were reported to be detectable by single-strand conformation polymorphism analysis. Here, we describe an assay using polymerase-chain-reaction-based amplification and subsequent enzymatic digestion of genomic sequences to identify polymorphic sites at nucleotide positions 1458 and 5037 of the APC gene.

引用

页码：705 / 706

页数：2

共 2 条

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