HUMAN CARBONYL AND ALDOSE REDUCTASES - NEW CATALYTIC FUNCTIONS IN TETRAHYDROBIOPTERIN BIOSYNTHESIS

被引：73

作者：

PARK, YS

HEIZMANN, CW

WERMUTH, B

LEVINE, RA

STEINERSTAUCH, P

GUZMAN, J

BLAU, N

机构：

[1] LAFAYETTE CLIN,MOLEC NEUROBIOL LAB,DETROIT,MI 48207

[2] UNIV BERN,DEPT CLIN CHEM,CH-3010 BERN,SWITZERLAND

[3] WAYNE STATE UNIV,DEPT PEDIAT,DETROIT,MI 48202

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 175卷 / 03期

关键词：

D O I：

10.1016/0006-291X(91)91628-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New catalytic functions of human carbonyl- and aldose reductase in tetrahydrobiopterin biosynthesis are proposed. 6-Pyruvoyltetrahydropterin, an intermediate in the biosynthesis of tetrahydrobiopterin, was converted to 6-lactoyl tetrahydropterin and 1′-hydroxy-2′-oxopropyl tetrahydropterin by carbonyl reductase under anaerobic condition. 1′-Hydroxy-2′-oxopropyl tetrahydropterin was subsequently metabolized to tetrahydrobiopterin by aldose reductase. Based on these results alternative pathways for the synthesis of tetrahydrobiopterin in patients with genetic defects of sepiapterin reductase are suggested. © 1991.

引用

页码：738 / 744

页数：7

共 25 条

[1]

BLAU N, 1988, ANNU REV NUTR, V8, P185

[2]

BLAU N, 1989, PTERIDINES BIOGENIC, P97

[3]

CURTIUS H-C, 1986, P141

[4] BIOSYNTHESIS OF TETRAHYDROBIOPTERIN IN MAN [J].

CURTIUS, HC ;

HEINTEL, D ;

GHISLA, S ;

KUSTER, T ;

LEIMBACHER, W ;

NIEDERWIESER, A .

JOURNAL OF INHERITED METABOLIC DISEASE, 1985, 8 :28-33

[5]

FERRE J, 1988, CLIN CHIM ACTA, V271, P271

[6] PURIFICATION AND CHARACTERIZATION OF 6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE FROM SALMON LIVER [J].

HASLER, T ;

CURTIUS, HC .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1989, 180 (01) :205-211

[7]

HEINTEL D, 1985, BIOCH CLIN ASPECTS P, V4, P151

[8]

KATOH S, 1970, CHEM BIOL PTERIDINES, P225

[9]

Kaufman S., 1974, MOL MECHANISMS OXYGE, P285

[10]

LEVINE RA, 1990, J NEUROCHEM, V54, P1219

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