ANTIGENIC VARIATION IN AFRICAN TRYPANOSOMES

被引：30

作者：

VANDERPLOEG, LHT

GOTTESDIENER, K

LEE, MGS

机构：

[1] COLUMBIA UNIV,DEPT GENET & DEV,NEW YORK,NY 10032

[2] COLUMBIA UNIV,DEPT MED,NEW YORK,NY 10032

[3] COLUMBIA UNIV,DIV TROP MED,NEW YORK,NY 10032

来源：

TRENDS IN GENETICS | 1992年 / 8卷 / 12期

关键词：

D O I：

10.1016/0168-9525(92)90330-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

African trypanosomes evade the humoral immune response by periodically changing the antigenic identity of their variant cell-surface glycoprotein (VSG) coat. Antigenic variation relies on DNA rearrangement events that can translocate a silent VSG gene to a telomerically located VSG gene expression site. Antigenic switches can also be brought about by the differential transcriptional control of the expression sites, only one of which is transcribed at any time.

引用

页码：452 / 457

页数：6

共 48 条

[1]

ABIRI D, 1989, P NATL ACAD SCI USA, V86, P9626

[2] TRANSSPLICING OF NUCLEAR PRE-MESSENGER-RNAS [J].