CYTOTOXIC ALKALOIDS OF ANNONA-MONTANA

被引：44

作者：

WU, YC ^{[1
]}

CHANG, GY ^{[1
]}

DUH, CY ^{[1
]}

WANG, SK ^{[1
]}

机构：

[1] KAOH SIUNG MED COLL,DEPT MICROBIOL,KAOHSIUNG 807,TAIWAN

来源：

PHYTOCHEMISTRY | 1993年 / 33卷 / 02期

关键词：

ANNONA-MONTANA; ANNONACEAE; ALKALOIDS; ANNORETINE; ANNOLATINE; CYTOTOXICITY;

D O I：

10.1016/0031-9422(93)85547-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The leaves of Annona montana afforded one novel cytotoxic phenanthrene alkaloid, annoretine [3-hydroxy-4-methoxy-N-methyl-tetrahydropyrido(4,3-a)phenanthrene], together with two cytotoxic alkaloids, argentinine and liriodenine, as well as a new oxoaporphine alkaloid, annolatine, and one steroid, sitosterol-beta-D-glucoside, which are inactive. The structures of annoretine and annolatine were elucidated from spectral data and chemical evidence.

引用

页码：497 / 500

页数：4

共 17 条

[1]

GERAN RI, 1972, CANC CHEMOTHER REP, V3, P1

[2] APORPHINOID ALKALOIDS .3. [J].

GUINAUDEAU, H ;

LEBOEUF, M ;

CAVE, A .

JOURNAL OF NATURAL PRODUCTS, 1983, 46 (06) :761-835

[3] APORPHINE ALKALOIDS .2. [J].

GUINAUDEAU, H ;

LEBOEUF, M ;

CAVE, A .

JOURNAL OF NATURAL PRODUCTS, 1979, 42 (04) :325-360

[4]

GUINAUDEAU H, 1975, LLOYDIA, V38, P275

[5] APORPHINOID ALKALOIDS .4. [J].

GUINAUDEAU, H ;

LEBOEUF, M ;

CAVE, A .

JOURNAL OF NATURAL PRODUCTS, 1988, 51 (03) :389-474

[6] ALKALOIDS OF THE ANNONACEAE .33. ANNOMONTINE AND METHOXYANNOMONTINE, 2 NEW PYRIMIDINE-BETA-CARBOLINE-TYPE ALKALOIDS FROM ANNONA-MONTANA [J].

LEBOEUF, M ;

CAVE, A ;

FORGACS, P ;

PROVOST, J ;

CHIARONI, A ;

RICHE, C .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1982, (05) :1205-1208

[7]

LEBOEUF M, 1982, Plantes Medicinales et Phytotherapie, V16, P169

[8]

LEE SS, 1992, TETRAHEDRON LETT, V33, P6309

[9]

LIU TS, 1960, ILLUSTRATION NATIVE, V1, P87

[10] ANNOQUINONE-A, AN ANTIMICROBIAL AND CYTOTOXIC PRINCIPLE FROM ANNONA-MONTANA [J].

WU, TS ;

JONG, TT ;

TIEN, HJ ;

KUOH, CS ;

FURUKAWA, H ;

LEE, KH .

PHYTOCHEMISTRY, 1987, 26 (06) :1623-1625

← 1 2 →