NOVEL ANTIBIOTICS SF2738A, SF2738B AND SF2738C, AND THEIR ANALOGS PRODUCED BY STREPTOMYCES SP

被引：51

作者：

GOMI, S

AMANO, S

SATO, E

MIYADOH, S

KODAMA, Y

机构：

[1] Pharmaceutical Research Center, Meiji Seika Kaisha Ltd., Yokohama 222, Morooka-cho, Kohoku-ku

来源：

JOURNAL OF ANTIBIOTICS | 1994年 / 47卷 / 12期

关键词：

D O I：

10.7164/antibiotics.47.1385

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Three new antibiotics SF2738A, B and C, and their analogs were isolated from the culture broth of Streptomyces sp. The antibiotics are active against Gram-positive bacteria, Gram-negative bacteria and fungi, and exhibited cytotoxic activity against P388 murine leukemia cells with IC50 values of 0.08, 0.25 and 7.5 mu g/ml, respectively. Their structures were determined by spectral analyses and chemical conversion. Especially, the structure of SF2738A was confirmed to be (E)-((4-methoxy-5-methylthio-2-(2-pyridyl)pyridin-6-yl)methylene)azanol by X-ray crystallographic analysis.

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页码：1385 / 1394

页数：10

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