COMPARTMENTAL MODELING BASED ON METHIONINE TOLERANCE-TEST DATA - CASE-STUDY

被引：6

作者：

BROWN, RF ^{[1
]}

GODFREY, KR ^{[1
]}

KNELL, A ^{[1
]}

机构：

[1] WARWICK HOSP,WARWICK,ENGLAND

来源：

MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING | 1979年 / 17卷 / 02期

关键词：

Metabolic systems; Modelling;

D O I：

10.1007/BF02440933

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

A case study illustrates the application of systems theory to the analysis of data from nonrepeatable experiments with relatively few data points. The specific problem considered is the compartmental modelling in the human of the metabolic pathways of orally-administered methionine using tolerance test data. Attention is restricted to linear models, and concentrates on the determination of parsimonious structures (i.e. with as few parameters as possible) and their physiological interpretation. © 1979 IFMBE.

引用

页码：223 / 229

页数：7

共 6 条

[1] REGIONAL VARIATIONS IN PROPORTION OF RED CELLS IN BLOOD IN MAN
BOWDLER, AJ
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 1969, 16 (06) : 557 - &
[2] Diem K., 1970, DOCUMENTA GEIGY SCI
[3] DISTEFANO JJ, 1976, AM J PHYSIOL, V230, P476
[4] Jacquez J.A., 1972, COMPARTMENTAL ANAL B
[5] APPLICATION OF A PROGRAMMABLE CALCULATOR IN DATA FITTING ACCORDING TO ONE AND 2 COMPARTMENT OPEN MODELS IN CLINICAL PHARMACOKINETICS
NIAZI, S
[J]. COMPUTER PROGRAMS IN BIOMEDICINE, 1977, 7 (01): : 41 - 44
[6] INTERPRETATION OF PLASMA CONCENTRATION-TIME CURVES AFTER ORAL DOSING
RONFELD, RA
BENET, LZ
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1977, 66 (02) : 178 - 180

← 1 →