AN EXPERT SYSTEM FOR THE CHOICE OF FACTORS FOR A RUGGEDNESS TEST IN LIQUID-CHROMATOGRAPHY

被引：27

作者：

VANLEEUWEN, JA ^{[1
]}

VANDEGINSTE, BGM ^{[1
]}

KATEMAN, G ^{[1
]}

MULHOLLAND, M ^{[1
]}

CLELAND, A ^{[1
]}

机构：

[1] PHILIPS SCI,CAMBRIDGE CB1 2PX,ENGLAND

来源：

ANALYTICA CHIMICA ACTA | 1990年 / 228卷 / 01期

关键词：

D O I：

10.1016/S0003-2670(00)80490-0

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Method validation is an important and costly step in the development of liquid chromatographic methods, especially for pharmaceutical samples. A ruggedness test is valuable for finding the analytical conditions which give the best performance. By varying the factors that influence method performance, it is possible to design a more rugged method before a study of reproducibility is started. The choice of the factors to test is important. An expert system is described for the selection of factors in ruggedness tests. The system proved satisfactory for 10 of the 11 cases of pharmaceutical formulations tested. © 1990.

引用

页码：145 / 153

页数：9

共 9 条

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