CELLULAR STRESS INDUCES A REDISTRIBUTION OF THE GLUCOSE TRANSPORTER

被引:76
作者
WIDNELL, CC
BALDWIN, SA
DAVIES, A
MARTIN, S
PASTERNAK, CA
机构
[1] ST GEORGE HOSP,SCH MED,DEPT CELLULAR & MOLEC SCI,LONDON SW17 0RE,ENGLAND
[2] ROYAL FREE HOSP,SCH MED,DEPT BIOCHEM,LONDON NW3 2PF,ENGLAND
[3] ROYAL FREE HOSP,SCH MED,DEPT PROD & MOLEC BIOL,LONDON NW3 2PF,ENGLAND
[4] ROYAL FREE HOSP,SCH MED,DEPT CHEM,LONDON NW3 2PF,ENGLAND
基金
英国惠康基金;
关键词
glucose transporter; hyperthermia; stress; translocation; virus infection;
D O I
10.1096/fasebj.4.6.2156742
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The mechanism by which cells increase their rate of glucose uptake in response to stress is unclear. Using an immunofluorescence technique to localize the glucose transporter protein in BHK cells, we found that hyperthermia, treatment with arsenite, infection with vesicular stomatitis virus or Semliki Forest virus, and treatment with insulin cause the transporter to move from an intracellular site in the perinuclear region to the plasma membrane; the degree of translocation correlates approximately with the increase in glucose uptake. We conclude that stress induces an insulin-like distribution of certain membrane proteins.
引用
收藏
页码:1634 / 1637
页数:4
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