INHIBITORY EFFECTS OF NEUROPEPTIDE-Y (NPY) ON CRF AND STRESS-INDUCED CECAL MOTOR RESPONSE IN RATS

被引:32
作者
JIMENEZ, M [1 ]
BUENO, L [1 ]
机构
[1] UNIV AUTONOMA BARCELONA,SCH VET,DEPT CELLULAR BIOL & PHYSIOL,BARCELONA,SPAIN
关键词
D O I
10.1016/0024-3205(90)90321-H
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The effects of NPY on CRF and stress-stimulated cecal motility were investigated by electromyography in rats. Intracerebroventricular (ICV) injection of NPY at 300 ng/kg significantly reduced the frequency of spike burst during the first 15 minutes after its administration while no effects was observed at a lower dose (150 ng/kg). Exposure to mental stress (MS) increased significantly (p<0.01) during 45 minutes, the frequency of cecal spike bursts. NPY (300 ng/kg) injected ICV, 30 minutes prior to MS periods abolished the excitatory effects induced by stress. The frequency of cecal spike bursts was also increased during the first 15-minutes following ICV injection of CRF (300 ng/kg). Prior (5 min) ICV administration of NPY (150 ng/kg) abolished the stimulatory effect of CRF on cecal motility. It is concluded that central administration of NPY suppresses the stress-induced cecal motor response probably by inhibiting the pathways involved in CRF mediation of these effects. © 1990.
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页码:205 / 211
页数:7
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