SYNTHESIS AND CYTOTOXICITY OF THE ACYCLIC (E)-DIENEDIYNE AND (Z)-DIENEDIYNE SYSTEMS RELATED TO NEOCARZINOSTATINE CHROMOPHORE

被引：48

作者：

NAKATANI, K

ARAI, K

HIRAYAMA, N

MATSUDA, F

TERASHIMA, S

机构：

[1] SAGAMI CHEM RES CTR, 4-4-1 NISHI OHNUMA, SAGAMIHARA, KANAGAWA 229, JAPAN

[2] SAGAMI CHEM RES CTR, 4-4-1 NISHI OHNUMA, SAGAMIHARA, KANAGAWA 229, JAPAN

[3] KYOWA HAKKO KOGYO CO LTD, TOKYO RES LABS, MACHIDA, TOKYO 194, JAPAN

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 16期

关键词：

D O I：

10.1016/0040-4039(90)80218-B

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of the title compounds could be achieved by featuring the Pd-catalyzed coupling reaction of stereo-defined (E)-and (Z)-enol triflates with an acetylene derivative. It was found that the acyclic (Z)-dienediyne system obviously exhibits in vitro cytotoxicity against P388 murine leukemia stronger than that for the corresponding (E)-isomer. © 1990.

引用

页码：2323 / 2326

页数：4

共 17 条

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