PERIPHERAL METABOLISM OF PARATHYROID-HORMONE

被引:244
作者
MARTIN, KJ [1 ]
HRUSKA, KA [1 ]
FREITAG, JJ [1 ]
KLAHR, S [1 ]
SLATOPOLSKY, E [1 ]
机构
[1] WASHINGTON UNIV,SCH MED,DEPT INTERNAL MED,DIV RENAL,ST LOUIS,MO 63110
关键词
D O I
10.1056/NEJM197911153012005
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
AFTER the radioimmunoassay for parathyroid hormone (PTH) was introduced by Berson et al. in 1963,1 initial enthusiasm for its clinical application was tempered because widely differing results were reported from several laboratories.2 3 4 5 The overlap of serum levels of immunoreactive PTH (iPTH) between normal subjects and patients with hyperparathyroidism ranged from 0 to 50 per cent. In addition, whereas Reiss and Canterbury3 reported that serum levels of iPTH were not reduced by calcium infusion in patients with parathyroid adenomas, Potts and his coworkers4 found marked suppression of serum iPTH levels in response to induced hypercalcemia in a similar group of patients. © 1979, Massachusetts Medical Society. All rights reserved.
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收藏
页码:1092 / 1098
页数:7
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